glyS [2019-03-30 18:21:35]

glycyl-tRNA synthetase (beta subunit)

locus: BSU25260

pI: 4.97

mw: 76.05 kDa

protein length: 679 aa

gene length: 2040 bp

function: translation

product: glycyl-tRNA synthetase (beta subunit)

essential: yes

ec: 6.1.1.14

synonyms: yqfK

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 2,605,730 2,607,769

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly) (according to Swiss-Prot)

Protein family

• class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)

Structure

• [PDB|1J5W] (from ''Thermotoga maritima'', 55% identity, 72% similarity)

Expression and Regulation

Operons

• genes: [gene|FD84CF3E05B81BD38D8C8FF5B04728FB3912D9B5|glyQ]-[gene|337BF226112A48C39A24E6D5C7A63F864502914C|glyS]
  description: [Pubmed|22383849]

  regulatory mechanism

  • [regulon|T-box|T-box]: anti-termination, [Pubmed|19258532,28531275], in [regulon|T-box|T-box]

  regulation

  • induced by glycine limitation ([protein|search|T-box]) [Pubmed|19258532,28531275]

References

• 15890195,15663928,19258532,15292140,16741230,26229106